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What is Phenibut?

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Allyson Pelletier LMFT

This content has been medically reviewed by Allyson Pelletier.

What is Phenibut?

Phenibut is a popular supplement, used by many to boost energy, reduce stress, and even improve cognitive function. First made available in Russia in the 1960s, the drug is now available online throughout the USA, and typically sold as an energy booster alongside vitamins and protein. But, while unregulated by the FDA, millions of people across the United States are now using it for everything from treating depression and anxiety to giving themselves an energy or cognitive boost at stressful jobs or while working out.

The drug, which was likely initially popularized on Reddit, has been available in the USA since early 2010. Today, it’s still legal to purchase it in pill and capsule form, but typically is only abvailable on the Internet. If you or a loved one is using Phenibut, or considering it, it’s important that you understand the risks, potential side effects, and how the drug works before doing so.

What is Phenibut and How Does It Work?

Phenibut is a GABA (gamma-aminobutyric acid) analogue, working as a GABA receptor agonist in the brain. The drug functions similarly to gabapentinoids like pregabalin (Lyciria), which are used to treat neuropathic pain, epilepsy, and generalized anxiety disorder, with a very similar drug-effect and side-effect profile. Currently, Phenibut is used in Russia and the Ukraine as a pharmaceutical drug, where it is used to treat insomnia, anxiety, depression, substance abuse, PTSD, and other disorders.

Phenibut achieves these effects by stimulating neuroreceptors like GABA and dopamine, reducing stress, pain, and anxiety throughout the body. Many studies correlate its effects to those of benzodiazepines like valium and Ativan.

It is also known to increase and extend the effects of other anxiety and depression medications, including antipsychotics, anticonvulsants, sedatives, opioids, and alcohol. Therefore, anyone taking prescription medication should be very careful of using a drug like Phenibut, as it will likely interfere with other medication being taken.

Most users take a dose of 250mg orally, kicking in after 60-120 minutes, and lasting anywhere from 4-9 hours. With a very long half-life, the drug stays in the system for long periods of time, even after the effects have worn off. Most users describe the high much like that of valium or other benzodiazepines, reporting a reduction in stress and anxiety, and sometimes more clear-headedness or ability to focus and concentrate. When used in combination with opioids and many other drugs, Phenibut increases and extends the lifespan of those drugs.

Phenibut Side Effects

While many people treat Phenibut as a miracle drug, it includes numerous side-effects and some of them can be life-threatening. Most users experience sedation, sleepiness, nausea, irritability or agitation, anxiety, headache, and dizziness alongside motor coordination and loss of balance. Most users also experience a Phenibut hangover, much like that of alcohol.

Common side effects include:

  • Water weight gain
  • Edema
  • Blurred Vision
  • Fatigue
  • Difficulty concentrating
  • Dizziness
  • Tremors

While moderate compared to the side effects of some other drugs, Phenibut side effects can last for 6 or more hours, and users cannot operate machinery and sometimes cannot function in normal situations while on the drug. Some users also experience allergic reactions or intolerance, which can be extreme.

Phenibut Overdose

Phenibut has a recommended dose of 250mg, but, many users quickly become tolerant. Those exceeding the recommended dose or taking more than about 850mg over about 6 hours may experience an overdose.

This is a risk for first-time users as well as those who have built up a tolerance. The most common causes of overdose are:

  1. A) the user thinks the pill isn’t working and takes more (Phenibut can take hours to kick in)
  2. B) The user still has a large amount of the drug active in the system (Phenibut remains active for up to 24 hours) and brings the total amount of Phenibut in the system over overdose level by taking more
  3. C) the user develops tolerance to the drug and takes too much in an attempt to get the original high

A Phenibut overdose is characterized by severe nausea and vomiting, low blood pressure, fatigue, unresponsiveness, renal impairment, and liver degeneration (at very high doses). A person experiencing a Phenibut overdose should be given active charcoal tablets when available and taken to the hospital.

Is Phenibut Addictive?

Phenibut is often taken by users believing it is a safe alternative to other forms of drugs but they are often mistaken. Phenibut quickly induces tolerance in users, who have to take more and more of the drug to maintain the same level of high when using. Even infrequent users sticking to the recommended 2x per week dose will experience withdrawal symptoms when detoxing, and symptoms can be severe.

However, the higher the normal dose and the more frequently the drug is used, the more difficulty users will have to quit Phenibut. Most studies compare Phenibut withdrawal to that of benzodiazepines such as Valium, with substance dependence and tolerance onset tracking about the same as other similar drugs.

Phenibut Withdrawal and Detox

Phenibut withdrawal symptoms kick in both when taking very high doses and when quitting the drug. Users experience severe anxiety, insomnia, irritability and anger, visual and auditory hallucinations, and psychosis. Users are recommended to seek out medical detox, to avoid detoxing in conditions where they might be operating heavy machinery, and to potentially taper off the drug if neither are available. Medical professionals recommend monitoring the liver and blood because of the risk of fatty liver disease.

Anyone using Phenibut moderately can likely attempt detox on their own without risk, but long-term and heavy users should contact their doctor, visit a detox clinic, or check into a hospital before quitting.

Getting Help for Phenibut Addiction

Phenibut can quickly cause tolerance and substance dependence, leading users to take more and more of the drug. Withdrawing can cause severe anxiety and depression, often leading users to relapse, taking more of the drug that quickly becomes the only thing making them feel good.

Like prescription medication, Phenibut can be highly addictive, dangerous, and side-effects can cause permanent damage. If you or a loved one is addicted to Phenibut, a treatment facility can help you to detox safely in a medically supported environment and then offer the mental and psychological care to treat the underlying issues behind substance use.

Getting help for Phenibut addiction is especially important for users who are self-medicating, treating co-occurring disorders including anxiety, depression, PTSD, and bipolar disorder with the drug. Each of these comorbid disorders contributes to substance abuse, makes it more difficult to quit, and can exacerbate the side-effects of the drug. At the same time, long-term substance abuse, including Phenibut, can worsen the symptoms of anxiety and depression, causing severe rebound and suicidal thoughts. Long-term use can worsen your symptoms and it may be dangerous for you to quit on your own.

A substance abuse treatment center will help you through detox, offering medical support and prescription medication to ease symptoms when necessary. Once clean, you’ll be given a complete mental and psychological evaluation to help identify comorbid disorders, underlying problems, and triggers – so that you can get the treatment you need to fully recover. You will also learn skills including stress and anxiety management to help you live a healthier and happier life without substances, so you can stay clean. No matter why you began using Phenibut, there is help.

Beginnings Treatment Centers is located in beautiful and sunny Southern California in Orange County, which has one of the strongest and most active recovery communities in the United States. If you or your loved one is struggling with alcoholism, call us today and speak with one of our experienced and professional intake advisors, we’re here to help.

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I can’t say enough good things about my experience here. The staff was absolutely amazing—compassionate, knowledgeable, and truly committed to helping people heal. I came in with significant health issues, and they went above and beyond to address and accommodate every one of them with care and respect. More importantly, they helped shift my entire perspective. Through their guidance and support, I found my path to sobriety. I’m leaving not only healthier, but with a renewed sense of purpose and hope. I will be forever grateful for what they’ve done for me. A very special thank you to Katie, David, Katilyn, Bret, Theo, and Dillian—you each made a lasting impact on my journey. Thank you from the bottom of my heart!
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The location of the facility is a nice and quiet neighborhood away from the sounds of busy roads, nice and cozy rooms perfect for the temporary stay needed to get well. The staff are hardworking, supportive and flexible according to the individual needs of each client. You become family when you come here. Thank you for the opportunity and the help you have provided me!
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Amazing place, helped me get back on my feet again and a great foundation for my recovery process. Thank you to the team! Would recommend to all
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I’ve been to many treatments, and by far this is the best place I’ve been too. If you’re struggling with substance abuse, or mental health issues this is the place you want to go to. They truly care.
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Thank you Elite Care Beginnings for everything! It was a blast being with you guys on my recovery journey! For my very first time in treatment, you guys made me feel very welcomed! I would highly recommend this place for anyone who’s looking to get help for recovery! Thank you again Elite!!
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Beginnings was definitely the place I needed to get my life under control, and help set me up for success. Definitely appreciate the fact that most of the staff were extremely helpful and willing to go out of their way to assist me. Shout out to Katie and Mikey For going out their way and taking me to the gym on the daily. This helped provide a strong routine, and consistency for me is essential in maintaining my sobriety. Helped me regain control over my life when it became unmanageable. Thanks.
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